The Impressive and Rapidly Expanding Knowledge Base on SARS

hree days after issuing a global alert (1) about cases of atypical pneumonia in several countries in southeast Asia, the World Health Organization (WHO) introduced the term SARS to the world's lexicon (2). Familiarity with the newly coined acronym for " severe acute respiratory syndrome " was immediate, fueled by fear and by virtually continuous coverage by the media. 1 This intense reaction and scrutiny would generate multifaceted outcomes, enabling widespread collaboration and communication to help curb the tragic health consequences while wreaking economic, social, and even political havoc in many areas. With similar speed, the clinical, public health, and research communities worldwide mounted an aggressive response to the new disease. Under the leadership of WHO, members of normally competitive groups worked together, often communicating several times a day, to acquire and share knowledge to stop the spread of disease. Events unfolded rapidly, requiring implementation of traditional control measures while generating in a matter of weeks an impressive body of knowledge about an unknown member of the coronavirus family. Scientific journals played a major role in this endeavor, expediting online publication of peer-reviewed data and other evolving information. The articles in this special SARS issue of Emerging Infectious Diseases are representative of this sustained involvement and commitment, with respect to both scope of authorship and range of topics. This diversity also illustrates the substantial contributions of many disciplines to the growing knowledge base on SARS. The articles describe findings from clinical and epidemiologic investigations , laboratory research, and social and behavioral studies , and discuss lessons learned both locally and globally. More than a decade ago, the Institute of Medicine (IOM) issued a report (3) on the continued risks of infectious diseases, outlining factors contributing to the increased emergence of such threats in a globalized era and steps that should be taken to adequately address them. Ironically, within a week of WHO's unprecedented global alert (1), the IOM released an updated report (4) on emerging microbial threats, expanding on the severity and scope of the problem. The new report describes issues affecting disease emergence such as international travel and commerce , environmental changes, poverty and inequity, and the adaptability of microbes, and strongly emphasizes the need for increased surveillance and response capacity on a global level. The emergence of SARS reinforced the urgency of the situation, serving as an impetus for fundamental changes in the way the global health community …